Equilibria and kinetics of biological macromolecules
Hermans, Jan
creator
Lentz, Barry
autor
text
bibliography
nju
2014
First Edition
monographic
eng
xxi, 499 pages : illustrations ; 24 cm.
Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules.
Part 1 Basic principles -- 1 Thermodynamics -- 2 Four basic quantum mechanical models of nuclear & electronic motion : a synopsis -- 3 Molecular structure and interactions -- 4 Water and the hydrophobic effect -- Part 2 Statistical mechanics: the molecular basis of thermodynamics -- 5 The molecular partition function -- 6 System ensembles and partition functions -- 7 Sampling molecular systems with simulations -- Part 3 Binding to macromolecules -- 8 Binding equilibria -- 9 Thermodynamics of molecular interactions -- 10 Elements of statistical mechanics of liquids and solutions -- 11 Analysis of binding equilibria in terms of partition functions -- 12 Coupled equilibria -- 13 Allosteric function -- 14 Charged groups : binding of hydrogen ions, solvation and charge-charge interactions -- Part 4 Conformational stability and conformation change -- 15 Some elements of polymer physics -- 16 Helix-coil equilibria -- 17 Protein unfolding equilibria -- 18 Elasticity of biological materials -- Part 5 Kinetics and irreversible processes -- 19 Kinetics -- 20 Kinetics of protein folding -- 21 Irreversible and stochastic processes.
Jan Hermans and Barry Lentz.
Includes index.
Includes bibliographical references.
Macromolecules
Biomedical materials
Molecular biology
Biophysics
Macromoléculas
Materiales biomédicos
Biología molecular
Biofísica
615.7 H5528e 2014
Equilibria and kinetics of biological macromolecules
Hermans, Jan.
Hoboken, N.J. : John Wiley & Sons, c2014
(DLC) 2013014670
9781118479704
EC-UrYT
130405
20200416183333.0