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Connexin methods and protocols / edited by Roberto Bruzzone and Christian Giaume.

Contributor(s): Bruzzone, Roberto [editor] | Giaume, Christian [editor].
Material type: materialTypeLabelBookSeries: Methods in molecular biology 154.Copyright date: Totowa, N.J. : Humana Press, 2001Edition: First Edition.Description: xiv, 491 pages : illustrations ; 24 cm.ISBN: 9780896036581; 0896036588.Subject(s): Connexins -- Laboratory manuals | Cytology | Connexins -- Manuales de laboratorio | CitologíaDDC classification: 571.64 Online resources: Publisher description | Table of contents only
Partial contents:
Part I. Tools to study connexins -- Part II. Assays for function -- Part III. Physiology and biology of connexins.
Abstract: An essential element in direct cell-cell communication between virtually all cell types in vertebrates, connexins have been recently linked to an increasing number of human genetic diseases. In Connexin Methods and Protocols, well established investigators describe in detail their best techniques for studying the cellular and molecular biology of connexins, as well as their physiological properties. These forefront methods are specifically designed to investigate the life of connexins from biosynthesis to assembly into gap junction channels, and also include powerful assays to perform functional studies on these routes of cell-cell communication. To ensure experimental success, each time-tested technique contains detailed step-by-step instructions, as well as tips on how to avoid pitfalls. Also discussed are the many specific theoretical aspects of connexin biology and physiology. Cutting-edge and highly practical, Connexin Methods and Protocols offers laboratory researchers a comprehensive collection of proven methods for studying the role of connexins in intercellular communication and human genetic disorders, as well as finding promising new therapeutics for those disorders.
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Item type Current location Call number Copy number Status Date due Item holds
Libro académico Libro académico Biblioteca del Campus
571.64 C75283 2001 (Browse shelf) Ej. 1 Available
Total holds: 0

Includes bibliographical references and index.

Part I. Tools to study connexins -- Part II. Assays for function -- Part III. Physiology and biology of connexins.

An essential element in direct cell-cell communication between virtually all cell types in vertebrates, connexins have been recently linked to an increasing number of human genetic diseases. In Connexin Methods and Protocols, well established investigators describe in detail their best techniques for studying the cellular and molecular biology of connexins, as well as their physiological properties. These forefront methods are specifically designed to investigate the life of connexins from biosynthesis to assembly into gap junction channels, and also include powerful assays to perform functional studies on these routes of cell-cell communication. To ensure experimental success, each time-tested technique contains detailed step-by-step instructions, as well as tips on how to avoid pitfalls. Also discussed are the many specific theoretical aspects of connexin biology and physiology. Cutting-edge and highly practical, Connexin Methods and Protocols offers laboratory researchers a comprehensive collection of proven methods for studying the role of connexins in intercellular communication and human genetic disorders, as well as finding promising new therapeutics for those disorders.

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