Includes index.

Includes bibliographical references.

1 Some Reflections on Chemistry - Molecular, Supramolecular and Beyond -- 2 Chemical Synthesis and Biological Studies of the Epothilones - Microtubule Stabilizing Agents with Enhanced Activity Against Multidrug-Resistant Cell Lines and Tumors -- 3 The Spirotetrahydrofuran Motif: its Role in Enhancing Ligation in Belted Ionophores, Biasing Cyclohezane Conformation, and Restricting Nucleoside/Nucleotide Conformation -- 4 Heterogeneous Catalysis: from "Black Art" to Atomic Understanding -- 5 Drugs for a New Millennium -- 6 Protein Folding and Beyond -- 7 The Enzymology of Biological Nitrogen Fixation -- 8 The Chemistry of Nitrogen in Soils -- 9 Spherical Molecular Assemblies: A Class of Hosts for the Next Millennium -- 10 The Combinatorial Approach to Materials Discovery -- 11 On One Hand But Not The Other: The Challenge of the Origin and Survival of Homochirality in Prebiotic Chemistry -- 12 Chemical Reaction Dynamics Looks to the Understanding of Complex Systems -- 13 The Past, Present, and Future of Quantum Chemistry -- 14 Quantum Alchemy -- 15 Quantum Theory Project.