Equilibria and kinetics of biological macromolecules / Jan Hermans and Barry Lentz.
By: Hermans, Jan.
Contributor(s): Lentz, Barry [autor].Material type: BookCopyright date: Hoboken, N.J. : Wiley, 2014Edition: First Edition.Description: xxi, 499 pages : illustrations ; 24 cm.ISBN: 9781118479704.Subject(s): Macromolecules | Biomedical materials | Molecular biology | Biophysics | Macromoléculas | Materiales biomédicos | Biología molecular | BiofísicaDDC classification: 615.7
|Item type||Current location||Call number||Copy number||Status||Date due||Item holds|
|Libro académico||Biblioteca del Campus||615.7 H5528e 2014 (Browse shelf)||Ej. 1||Available|
Includes bibliographical references.
Part 1 Basic principles -- 1 Thermodynamics -- 2 Four basic quantum mechanical models of nuclear & electronic motion : a synopsis -- 3 Molecular structure and interactions -- 4 Water and the hydrophobic effect -- Part 2 Statistical mechanics: the molecular basis of thermodynamics -- 5 The molecular partition function -- 6 System ensembles and partition functions -- 7 Sampling molecular systems with simulations -- Part 3 Binding to macromolecules -- 8 Binding equilibria -- 9 Thermodynamics of molecular interactions -- 10 Elements of statistical mechanics of liquids and solutions -- 11 Analysis of binding equilibria in terms of partition functions -- 12 Coupled equilibria -- 13 Allosteric function -- 14 Charged groups : binding of hydrogen ions, solvation and charge-charge interactions -- Part 4 Conformational stability and conformation change -- 15 Some elements of polymer physics -- 16 Helix-coil equilibria -- 17 Protein unfolding equilibria -- 18 Elasticity of biological materials -- Part 5 Kinetics and irreversible processes -- 19 Kinetics -- 20 Kinetics of protein folding -- 21 Irreversible and stochastic processes.
Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules.